Published Manuscripts

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Incline’s investigational product candidate, IONSYS, is supported by a significant number of published clinical and scientific manuscripts.

Ahmad S, Hewitt DJ, Damaraju CV.
Fentanyl HCl iontophoretic transdermal system versus intravenous morphine pump after gynecologic surgery
Arch Gynecol Obstet. 2007;276(3):251-258.

Bonnet F, Eberhart L, Wennberg E, Dodds SJ, Van Bellinghen L, Annemans L, Kavanagh S, Choe Y.
Fentanyl HCI iontophoretic transdermal system versus morphine IV-PCA for postoperative pain management: survey of healthcare provider opinion
Curr Med Res Opin. 2009;25(2):293-301.

Bourne MH, Chelly JE, Damaraju CV, Nelson WW, Schein JR, Hewitt DJ.
Physical therapists’ perceptions of ease of care in patients receiving 2 forms of analgesia after total hip arthroplasty.
Phys Ther

Chelly JE.
An iontophoretic, fentanyl HCl patient-controlled transdermal system for acute postoperative pain management
Expert Opin Pharmacotherapy. 2005; 6(7): 1205-1214.

Chelly JE, Grass J, Houseman TW, Minkowitz H, Pue A.
The safety and efficacy of a fentanyl patient-controlled transdermal system for acute postoperative analgesia: a multicenter placebo-controlled trial
Anesth Analg. 2004;98(2):427-433.

Eberhart L.
The safety and tolerability of the fentanyl HCl iontophoretic transdermal system: an alternative to currently available analgesic modalities
J Opioid Manag. 2007;3(5):249-256.

Evans C, Schein J, Nelson W, Crespi S, Gargiulo K, Horowicz-Mehler N, Panchal S.
Improving patient and nurse outcomes: a comparison of nurse tasks and time associated with two patient-controlled analgesia modalities using delphi panels
Pain Manag Nurs. 2007;8(2):86-95.

Grond S, Hall J, Spacek A, Hoppenbrouwers M, Richarz U, Bonnet F.
Iontophoretic transdermal system using fentanyl compared with patient-controlled intravenous analgesia using morphine for postoperative pain management
Br J Anaesth. 2007;98(6):806-815.

Harding G, Vallow S, Leidy NK, Olson W, Hewitt DJ, Polomano R, Nelson WW, Schein JR.
Ease of care with patient controlled analgesia systems: questionnaire development and validation
J Adv Nurs. 2007;59(5):530-541

Harding G, Schein JR, Nelson WW, Vallow S, Olson WH, Hewitt DJ, Polomano RC.
Development and validation of a new instrument to evaluate the ease of use of patient-controlled analgesia modalities for postoperative patients
J Med Econ. 2010;13(1):42-54.

Hartrick CT.
Patient-controlled transdermal iontophoretic fentanyl system as an alternative to intravenous morphine PCA
Future Neurol. 2007;2(6):621-627.

Hartrick CT, Bourne MH, Gargiulo K, Damaraju CV, Vallow S, Hewitt DJ.
Fentanyl iontophoretic transdermal system for acute-pain management after orthopedic surgery: a comparative study with morphine intravenous patient-controlled analgesia
Reg Anesth Pain Med. 2006;31(6):546-554.

Koo PJ.
Postoperative pain management with a patient-controlled transdermal delivery system for fentanyl
Am J Health Syst Pharm. 2005;62(11):1171-1176.

Kotey GA, Knaggs RD.
Iontophoretic delivery of fentanyl for acute postoperative pain management
Eur J Hosp Pharm Sci. 2007;1(13):3-9.

Lindley P, Pestano CR, Gargiulo K.
Comparison of postoperative pain management using two patient-controlled analgesia methods: nursing perspective. J Adv Nurs. 2009.

Mattia C, Coluzzi F.
Acute postoperative pain management: focus on iontophoretic transdermal fentanyl
Ther Clin Risk Manag. 2007;3(1):19-27.

Minkowitz HS, Rathmell JP, Vallow S, Gargiulo K, Damaraju CV, Hewitt DJ.
Efficacy and safety of the fentanyl iontophoretic transdermal system (ITS) and intravenous patient-controlled analgesia (IV PCA) with morphine for pain management following abdominal or pelvic surgery. Pain Med. 2007.

Minkowitz HS, Yarmush J, Donnell MT, Tonner PH, Damaraju CV, Skowronski RJ.
Safety and tolerability of fentanyl iontophoretic transdermal system: Findings from a pooled data analysis of four clinical trials. Anesth Analg. 2010.

Miaskowski C.
Patient-controlled modalities for acute postoperative pain management
J Perianesth Nurs. 2005;20(4):255-67.

Panchal SJ, Damaraju CV, Nelson WW, Hewitt DJ, Schein JR.
System-related events and analgesic gaps during postoperative pain management with the fentanyl iontophoretic transdermal system and morphine intravenous patient-controlled analgesia
Anesth Analg. 2007;105(5):1437-1441.

Pennington P, Caminiti S, Schein JR, Hewitt DJ, Nelson WW.
Patients’ assessment of the convenience of fentanyl HCl iontophoretic transdermal system (ITS) versus morphine intravenous patient-controlled analgesia (IV PCA) in the management of postoperative pain after major surgery
Pain Manag Nurs. 2009;10(3):124-33.

Power I.
Fentanyl HCl iontophoretic transdermal system (ITS): clinical application of iontophoretic technology in the management of acute postoperative pain
Br J Anaesth. 2007;98(1):4-11.

Rawal N, Langford RM.
Current practices for postoperative pain management in Europe and the potential role of the fentanyl HCl iontophoretic transdermal system
Eur J Anaesthiol. 2007;24(4):299-308.

Sathyan G, Phipps B, Gupta SK.
Passive absorption of fentanyl from the fentanyl HCl iontophoretic transdermal system
Curr Med Res Opin. 2009;25(2):363-366.

Viscusi ER.
Patient-controlled drug delivery for acute postoperative pain management: a review of current and emerging technologies
Reg Anesth Pain Med. 2008;33(2):146-158.

Viscusi ER, Reynolds L, Tait S, Melson T, Atkinson LE.
An iontophoretic fentanyl patient-activated analgesic delivery system for postoperative pain: a double-blind, placebo-controlled trial.
Anesth Analg. 2006;102(1):188-194.

Viscusi ER, Reynolds L, Chung F, Atkinson LE, Khanna S.
Patient-controlled transdermal fentanyl hydrochloride vs intravenous morphine pump for postoperative pain: a randomized controlled trial.
JAMA. 2004;291(11):1333-1341.

Viscusi ER, Siccardi M, Damaraju CV, Hewitt DJ, Kershaw P.
The safety and efficacy of fentanyl iontophoretic transdermal system compared with morphine intravenous patient-controlled analgesia for postoperative pain management: an analysis of pooled data from three randomized, active-controlled clinical studies
Anesth Analg. 2007;105(5):1428-1436.

Viscusi ER, Witkowski TA.
Iontophoresis: the process behind noninvasive drug delivery
Reg Anesth Pain Med. 2005;30(3):292-294.